The collision occurred shortly after 7 a.m. EDT Thursday on Highway 22 in Pendleton County.
State police dispatcher Amy Wyatt said one person died in the crash, but she didn't know whether the victim was a student or an adult. State police did not immediately release details about what caused the crash.
CBS News affiliate WKRC-TV in Cincinnati reports that according to parents of other students in the crash, the fatality was a teenage boy.
WKRC spoke with Ron Hess, an area resident who lives right across from the crash scene. He says there were eleven children total on the bus. Hess say he took ten injured children into his home and helped keep everyone calm until paramedics arrived.
A dozen injured people, mostly children, were taken to St. Elizabeth Medical Center in nearby Grant County. Hospital spokeswoman Christa Moore said 10 children and both drivers are being treated for what appears to be minor injuries.
The hospital has declined comment on the condition of the truck driver, reports WKRC reports.