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Rosemary Kennedy
Rosemary Kennedy, the third child of Joseph Patrick Kennedy and his wife Rose, is institutionalized because of retardation and a failed full frontal lobotomy.
Joseph P. Kennedy
Joseph P. Kennedy Jr., the eldest son of Joseph and Rose Kennedy, is killed at age 29 when his plane explodes over the English Channel while on a secret World War II bombing mission.
Kathleen Kennedy
Just 28, Kathleen Kennedy, daughter of Joseph and Rose Kennedy, dies with her lover when a small plane crashes in the south of France.
John F. Kennedy and Jacqueline
Patrick Bouvier Kennedy, the second son born to John F. and Jacqueline Kennedy, is born nearly six weeks premature on Aug. 7. He dies two days later of respiratory ailments.
JFK, Jr salutes casket of his father 
John F. Kennedy, the 35th president of the United States, is assassinated in Dallas on November 22.
Edward M. Kennedy 
Massachusetts Senator Edward M. Kennedy, brother of John F. Kennedy and Robert F. Kennedy, is critically injured in a June plane crash.
Robert Kennedy lies on floor after being shot
Robert F. Kennedy, who served as attorney general under his older brother President John F. Kennedy, is assassinated in Los Angeles while running for president at age 42.
Wearing neckbrace after car accident. 
Edward M. Kennedy's dreams of a presidential bid are dashed when he drives a car off a bridge on Massachusetts' Chappaquiddick Island July 18 after a party. Aide Mary Jo Kopechne is later found dead in the submerged car.
Joseph Patrick Kennedy III, one of seven sons of Robert and Ethel Kennedy, is involved in a car accident that leaves a female passenger paralyzed for life. Edward Moore Kennedy 
Edward Moore Kennedy Jr., son of Edward and Joan Kennedy, has his right leg amputated because of bone cancer. Later, in 1985 he founds Facing the Challenge, a nonprofit group devoted to people with physical and mental disabilities.
David Anthony Kennedy, son of Robert F. Kennedy, dies of a heroin overdose in a hotel near a family vacation home in Palm Beach, Fla. Patrick Joseph Kennedy
Two-term U.S. Rep. Patrick Joseph Kennedy, son of Edward and Joan Kennedy, seeks treatment for cocaine addiction as a teen-ager.
William Kennedy Smith
William Kennedy Smith, son of Jean Kennedy and Stephen Smith, is accused of raping a woman at the family's Palm Beach estate. He is acquitted later that year.
Michael LeMoyne Kennedy 
Son of Robert F. and Ethel Kennedy, Michael LeMoyne Kennedy, who was accused of having an affair with his family's teen-age baby sitter, was killed on December 31 in a skiing accident in Aspen, Colo. He was 39.
JFK and Carolyn 
John F. Kennedy Jr., his wife Carolyn Bessette Kennedy and her older sister Lauren Bessette are killed when Kennedy's single-engine plane crashes off the coast of Martha's Vineyard, Mass.
Ted Kennedy 
Sen. Edward M. (Ted) Kennedy, one of American politics' most enduring figures, is diagnosed with a cancerous brain tumor. Tests were conducted after the 76-year-old Massachusetts Democrat had a seizure at his home on Cape Cod.