April 29, 2012 7:05 PM

Hooked: Why bad habits are hard to break

Morley Safer: By the time you came here, how many of your close family had been executed?

Esteban Volkow: Well, I think, most all.

Esteban Volkow is Nora Volkow's father, Trotsky's grandson. 73 years ago, he came to live here with Trotsky. He was 13 years old, an orphan. His parents, victims of the Stalinist terror.

Nora Volkow: His mother committed suicide. His father was killed in a concentration camp. He then ended up with Trotsky because he was the person that was responsible for him.

A year after his arrival, in the dead of night, there was a machine gun attack on the house by Stalinist agents. Trotsky was unhurt. Esteban hid behind his bed.

Esteban Volkow: They shoot in my bed, yes, about six, seven bullets -

Morley Safer: You got hit by one of the bullets.

Esteban Volkow: Yes, only a scratch, yes.

Watch towers were built on the house. But just three months later, Stalin finally got his man.

Esteban Volkow: I saw that something strange was happening in the house.

An assassin made his way into Trotsky's office and pierced his skull with an ice axe. August 20th, 1940.

Esteban Volkow: I came in the library and to a little opening, I could see my grandfather on the floor with Natalia. And he was blood around him. And he give the instruction "Keep the boy away. I don't want him to see - "

Morley Safer: He was still conscious?

Esteban Volkow: Sure, sure.

Doctors did what they could, but Trotsky died a day later. He's buried in the family garden. Esteban Volkow went on to become a chemist who helped develop the birth control pill. Nora Volkow was born 15 years after Trotsky's death. Addicted, since childhood, to the pursuit of science.

Patricia Volkow: There was a Christmas that the only doll was for me and there was a microscope that was for her, OK?

She has three sisters. Veronica, a writer. Patricia, a doctor in a public hospital, and Natalia, a government statistician.

Natalia Volkow: I think yes, we all have this sense of public service, social consciousness, responsibility towards not only yourself as individual, but for your society.

Morley Safer: Are you proud of the accomplishments of your kids?

Esteban Volkow: More or less. (laughter)

The road from the house of ghosts in Mexico has taken Nora Volkow to a place of influence in Washington. She starts each day with a seven-mile run, getting a healthy dose of dopamine. And looking forward down the road, she sees a day when science might banish the curse of addiction.

Nora Volkow: A cure would be fantastic. And that means you get a medication like an antibiotic. I cure you.

Volkow's labs and others around the country are working to develop vaccines to block drugs from entering the brain. The complexities are enormous, and progress is slow.

Nora Volkow: We're not there yet. But perhaps one day we may be. And in my brain, if you don't dare to think very ambitious things, you'll never be there.



© 2012 CBS Interactive Inc. All Rights Reserved.
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